TABLE 1

Efficacy of A2M-PMB in protection of mice against LPS lethality

Dose/Time of Administration
No. Dead Mice/Total
Survival
%
A2M-PMB: 25 μg/g; 30 min before LPS 6/10 40
A2M-PMB: 50 μg/g; 30 min before LPS 0/10* 100
A2M-PMB: 250 μg/g; 30 min before LPS 1/10* 90
A2M-PMB: 25 μg/g; 30 min after LPS 5/10 50
A2M-PMB: 50 μg/g; 30 min after LPS 4/10 60
A2M-PMB: 250 μg/g; 30 min after LPS 3/10 70
Controla 20/21 5
Dextran-PMBb: 26 μg/g; 30 min before LPS
7/12
42

  • ↵* A2M-PMB versus control (P < 0.05)

  • ↵ a Control mice were given 250 μl of PBS intraperitoneally 30 min before LPS

  • ↵ b This amount is equivalent to 250 μg/g A2M-PMB on basis of the PMB content