TABLE 2

Effect of serotonin or norepinephrine selective drugs on hippocampal VMAT-2 uptake Rats received one injection of methiothepin (5HT_{1, 6, and 7}; 10 mg/kg i.p.), fluoxetine (serotonin reuptake inhibitor; 10 mg/kg i.p.), citalopram (serotonin reuptake inhibitor; 10 mg/kg i.p.), CP93129 (5HT_1b agonist; 2 mg/kg i.p.), yohimbine (α 2-adrenergic receptor antagonist; 10 mg/kg i.p.), desipramine (norepinephrine reuptake inhibitor; 10 mg/kg i.p.), or water vehicle (1 ml/kg i.p.). Animals were sacrificed 1 h after injection. Data are expressed as the percentage of the mean control values ± 1 S.E.M. of determinations in six rats. Control values ranged from 14.3 to 17.6 fmol/μg protein.