TABLE 2

Potency and relative efficacy of phospholipids on GPR92 pEC50 is the -log molar concentration of substance resulting in 50% of maximal reporter gene expression. Average value is the mean ± S.E.M. of the number of experiments performed. Relative efficacy of LPA 18:1 was set to 100%.


Name

pEC50

Relative Efficacy

n
LPA 18:1 5.03 ± 0.13 100 6
LPA 18.0 5.12 ± 0.19 127 ± 14.6 6
LPA 16:0 6.40 ± 0.36 117 ± 21 6
LPA 14.0 6.08 ± 0.31 95 ± 19 5
LPC 18:1 4.13 ± 0.37 N.D. 3
LPC 20:0 <4.00 N.D. 3
LPE 18:1 <4.00 N.D. 3
LPS 18:1 4.4 and 4.1 N.D. 2
LPG 18:1 <4.00 N.D. 3
S1P 18:1 <4.00 N.D. 3
DGPP 8:0
<4.00
N.D.
3
  • N.D., not determined