TABLE 1

Gene ontology of microarray data

GO ID
GO Name
No. of Regulated Genes
No. of Genes in GO Group
Genes regulated by estradiol, but not 4-OH-Tam or Endoxifen (1856)
   GO:42221 Response to chemical substance 24 208
   GO:43085 Positive regulation of enzyme activity 12 93
   GO:6352 Transcription initiation 12 49
   GO:48666 Neuron development 9 59
   GO:50793 Regulation of development 9 65
   GO:6367 Transcription initiation from RNA polymerase II promo 9 30
   GO:6575 Amino acid derivative metabolism 9 46
   GO:6665 Sphingolipid metabolism 9 39
   GO:904 Cellular morphogenesis during differentiation 9 52
   GO:51261 Protein depolymerization 8 27
   GO:31175 Neurite morphogenesis 7 47
   GO:48667 Neuron morphogenesis during differentiation 7 47
   GO:6576 Biogenic amine metabolism 7 40
   GO:6695 Cholesterol biosynthesis 7 22
   GO:16569 Covalent chromatin modification 6 23
   GO:16570 Histone modification 6 23
   GO:18193 Peptidyl-amino acid modification 6 29
   GO:8624 Induction of apoptosis by extracellular signals 6 29
   GO:9991 Response to extracellular stimulus 6 18
   GO:42133 Neurotransmitter metabolism 5 17
   GO:7031 Peroxisome organization and biogenesis 5 16
   GO:7584 Response to nutrients 5 16
   GO:9225 Nucleotide-sugar metabolism 5 15
Genes regulated by estradiol and 4-OH-Tam and endoxifen (1365)
   GO:19932 Second-messenger-mediated signaling 22 176
   GO:51321 Meiotic cell cycle 10 44
   GO:51327 M phase of meiotic cell cycle 10 44
   GO:7126 Meiosis 10 44
   GO:6869 Lipid transport 8 61
   GO:31570 DNA integrity checkpoint 6 10
   GO:42770 DNA damage response, signal transduction 6 15
   GO:48511 Rhythmic process 6 27
   GO:6766 Vitamin metabolism 6 40
   GO:6767 Water-soluble vitamin metabolism 5 29
   GO:7127 Meiosis I 5 21
   GO:7548 Sex differentiation 5 33
   GO:9262 Deoxyribonucleotide metabolism 5 7
Genes regulated by endoxifen, but neither estradiol nor 4-OH-Tam (389)
   GO:30001 Metal ion transport 13 307
   GO:6816 Calcium ion transport 6 71
Genes regulated by 4-OH-Tam, but neither estradiol nor endoxifen (376)
   GO:9611 Response to wounding 12 347
   GO:6968 Cellular defense response 6 88
   GO:15849 Organic acid transport 5 60
   GO:46942 Carboxylic acid transport 5 60
Genes regulated by endoxifen and 4-OH-Tam, but not estradiol (249)
   GO:6959 Humoral immune response 5 150
Genes regulated by estradiol and 4-OH-Tam, but not endoxifen (454)
   None
Genes regulated by estradiol and endoxifen, but not 4-OH-Tam (387)
   None