Activity of PS200981 and PS166276 at a panel of kinases A panel of kinases was evaluated for activity of PS200981 and PS166276 at ≤ Km [ATP]. IC50 values are in micromolars.
Kinase | PS200981 | PS166276 | Kinase | PS200981 | PS166276 | |
|---|---|---|---|---|---|---|
| μM | ||||||
| p38α | 1.0 | 0.028 | IGF-1R | >50 | >50 | |
| p38β | 1.1 | 0.014 | IKKβ | >50 | >50 | |
| p38γ | >100 | >100 | JNK1α1 | >50 | >50 | |
| Abl | 25 | >50 | JNK2α2 | >50 | >50 | |
| Aurora-A | >50 | >50 | KDR | >50 | >50 | |
| BTK | >50 | >50 | Lck | >50 | >50 | |
| CaMKIV | >50 | >50 | Mapkap K2 | >50 | >50 | |
| CDK1/cyclinB | >50 | >50 | Met | >50 | >50 | |
| CHK1 | >50 | >50 | NEK2 | >50 | >50 | |
| CK1δ | >50 | >50 | PAK4 | >50 | >50 | |
| CK2 | >50 | >50 | PDK1 | >50 | >50 | |
| CSK | >50 | 32 | PKA | >50 | >50 | |
| EGFR | >50 | >50 | PKBb | >50 | >50 | |
| EphB4 | >50 | >50 | PKCa | >50 | >50 | |
| ERK1 | >50 | >50 | PKCθ | >50 | >50 | |
| ERK2 | >50 | >50 | ROCK-II | >50 | >50 | |
| FGFR3 | >50 | >50 | Rsk2 | >50 | >50 | |
| Flt3 | >50 | >50 | Src | >50 | >50 | |
| GSK3β | >50 | >50 | Tie2 | 37 | >50 | |
| Flt1 | >50 | >50 | Zap-70 | >50 | >50 | |