TABLE 2

Levels of paclitaxel and docetaxel in the soluble fraction of human myocardial strips exposed to doxorubicin and taxanes-vehicles formulations Human myocardial strips were incubated in plasma and exposed to 10 μM doxorubicin and 2 to 15 μM paclitaxel or docetaxel formulated in their cosolvent systems (10 μl of ethanol/ml + 10 μl of Cremophor EL/ml, or 1 μl of ethanol/ml + 1 μl of polysorbate 80/ml, respectively). After 4 h, the soluble fraction of the strips was assayed for paclitaxel or docetaxel as described under Materials and Methods. All of the values were means ± S.E. of three to six experiments and were analyzed by one-way analysis of variance/Bonferroni's test for multiple comparisons; where indicated, unpaired Student's t test was also applied.