Respiratory Substrate(s) | Nimesulide | Albumin (36 g/l) | Respiratory Rate | RCR | ||
---|---|---|---|---|---|---|
State 3 | State 4 | |||||
μM | natom O / min / mg protein | |||||
Malate + glutamate | 0 | – | 95 ± 6 | 9 ± 1 | 10.2 ± 0.6 | |
Malate + glutamate | 25 | – | 103 ± 3 | 29 ± 5* | 3.9 ± 0.7* | |
Malate + glutamate | 50 | – | 119 ± 8 | 35 ± 6* | 3.5 ± 0.6* | |
Malate + glutamate | 50 | + | 102 ± 6 | 10 ± 3 | 12.7 ± 4.7 | |
Succinate | 0 | – | 157 ± 25 | 39 ± 15 | 7.1 ± 1.7 | |
Succinate | 25 | – | 167 ± 5 | 48 ± 9 | 3.7 ± 0.7* | |
Succinate | 50 | – | 171 ± 17 | 80 ± 19* | 2.3 ± 0.3* | |
Succinate | 50 | + | 215 ± 49 | 23 ± 4 | 6.9 ± 0.9 |
↵* Different from the corresponding control, P < 0.05