SD-282 lowers COX-2, IL-β, and Il-6 expression in the joint tissue of CIA mice with advanced disease
Groups | Scoring for Immunohistochemical Staining | ||||
|---|---|---|---|---|---|
| COX-2 | IL-1β | IL-6 | |||
| mean ± S.D. | |||||
| Naïve (n = 3) | 0 | 0 | 0 | ||
| Baseline (n = 6) | 2.58 ± 0.74 | 3.0 ± 0.45 | 0.58 ± 0.66 | ||
| Vehicle (n = 12) | 2.67 ± 0.49 | 2.13 ± 1.11 | 3.42 ± 0.79 | ||
| SD-282 at 90 mg/kg (n = 12) | 1.17 ± 1.25 | 0.88 ± 1.09 | 2.17 ± 1.34 | ||
| p value* | <0.01 | <0.02 | <0.007 | ||
↵* p value for SD-282 treatment group compared to the vehicle group