Effects of BINA on startle amplitude of the acoustic startle reflex Data are expressed as means ± S.E.M. when the background noise stimulus (65 dB) or the pulse stimulus (120 dB) was presented alone.
Treatment Dose | Startle Amplitude | ||
|---|---|---|---|
| 65 | 120 | ||
| dB | |||
| Vehicle ± water | 200.4 ± 28.6 | 765.3 ± 70.2 | |
| BINA (32 mg/kg i.p.) ± water | 211.9 ± 31.1 | 817.3 ± 101.7 | |
| BINA(100 mg/kg i.p.) ± water | 100.1 ± 10.5 | 766.9 ± 73.4 | |
| Vehicle ± PCP (5.6 mg/kg i.p.) | 418.5 ± 80.0* | 666.4 ± 59.0 | |
| BINA (32 mg/kg i.p.) ± PCP (5.6 mg/kg i.p.) | 259.9 ± 37.9 | 721.2 ± 49.9 | |
| BINA (100 mg/kg i.p.) ± PCP (5.6 mg/kg i.p.) | 117.3 ± 17.1 | 654.8 ± 106.5 | |
| BINA (100 mg/kg i.p.) ± LY341495 (3 mg/kg i.p.) ± PCP (5.6 mg/kg i.p.) | 151.9 ± 13.7 | 590.0 ± 74.2 | |
| Vehicle ± LY341495 (3 mg/kg i.p.) ± PCP (5.6 mg/kg i.p.) | 249.4 ± 17.5 | 548.4 ± 67.5 | |
↵* P < 0.05 compared with control (i.e., vehicle ± water)