TABLE 3

IC50 of ML120B on IL-1β or TNF-stimulated cytokines/chemokines and MMP production




IL-1β sti IC50

S.D.

Donor Tested

TNFα sti IC50

S.D.

Donor Tested
μM μM
IL-6 5.7 2.2 5 14.5 12.1 6
IL-8 7.3 5.0 4 8.9 4.2 3
MCP-1 1.8 1.5 6 1.6 1.7 6
RANTES 0.8 0.6 6 0.7 0.5 6
MMP-1 9.7 1.2 2 2.8 0.9 3
MMP-3 1.9 2.0 3 2.0 0.6 3
MMP-13
1.9
1.6
3
0.9
0.3
3
  • sti, stimulated.