Hill equation curve fit parameters of the concentration-effect curves in the stomach and the left and right atria
Agonist | pEC50 | α | nH |
|---|---|---|---|
| Stomach: inotropic effect | |||
| 5-HT | 8.41 ± 0.09 | 87.1 ± 8.1 | 0.70 ± 0.04 |
| Prucalopride | 8.25 ± 0.07 | 91.8 ± 7.1 | 0.92 ± 0.04 |
| Tegaserod | 8.15 ± 0.10 | 92.8 ± 7.8 | 0.61 ± 0.04 |
| R149402 | 9.59 ± 0.09** | 60.6 ± 8.0** | 1.10 ± 0.07 |
| R199715 | 9.91 ± 0.08** | 54.6 ± 7.2** | 1.07 ± 0.07 |
| Left atrium: inotropic effecta | |||
| 5-HT | 7.71 ± 0.10 | 88.7 ± 5.2 | 0.93 ± 0.07 |
| Prucalopride | 7.70 ± 0.09 | 64.3 ± 6.7** | 0.86 ± 0.05 |
| Tegaserod | 6.85 ± 0.17** | 93.5 ± 6.8 | 0.58 ± 0.02 |
| R149402 | 8.97 ± 0.08** | 51.6 ± 5.5** | 0.86 ± 0.05 |
| R199715 | 8.94 ± 0.09** | 32.8 ± 6.7** | 0.91 ± 0.06 |
| Right atrium: chronotropic effecta | |||
| 5-HT | 6.53 ± 0.14 | 54.4 ± 4.8 | 0.87 ± 0.05 |
| Prucalopride | 7.01 ± 0.14* | 27.6 ± 4.6** | 1.16 ± 0.11 |
| Tegaserod | 6.58 ± 0.17 | 57.6 ± 5.7 | 0.62 ± 0.04 |
| R149402 | 8.53 ± 0.15** | 16.3 ± 4.2** | 1.30 ± 0.16 |
| R199715 | 8.70 ± 0.17** | 25.6 ± 5.4** | 1.23 ± 0.15 |