TABLE 1

Effect of acetylcholine inhibitors and σ1 receptor ligands against CO-induced learning impairments in mice

Drug Treatment
Test
Learning and Memory
Morphological Examination
Active Dose (or Dose Range Tested)
BD1047 Sensitivity
Cell Loss Protection
BD1047 Sensitivity
Antiamnesic effect
    Igmesine SA, PA 0.3-3 mg/kg ++
    Donepezil SA, PA 0.25-1 mg/kg ++ (SA), + (PA)
    Tacrine SA, PA 1 mg/kg -
    Rivastigmine SA, PA 0.3-1 mg/kg -
    Galanthamine SA, PA 1 mg/kg -
Preinsult neuroprotective effect
    Igmesine SA, PA 1-3 mg/kg ++ ++ ++
    Donepezil SA, PA 0.25-1 mg/kg ++ ++ +
    Tacrine SA, PA 0.3-1 mg/kg - -
Rivastigmine SA, PA 0.3-1 mg/kg - -
    Galanthamine SA, PA 1 mg/kg - + -
Postinsult neuroprotective effect
    Igmesine SA, PA 0.3-1 mg/kg ++ (SA), + (PA) ++ ++
    Donepezil SA 0.25-1 mg/kg + ++ ++
PA 0.5-1 mg/kg +
    Tacrine SA, PA (0.5-1 mg/kg) -
    Rivastigmine SA 1 mg/kg - -
PA (0.3-1 mg/kg)
    Galanthamine SA 1 mg/kg - -
PA
(0.3-1 mg/kg)

  • SA, spontaneous alternation; PA, passive avoidance; -, ineffective; +, partially effective; ++, fully effective.