Body weights at weaning and self-administration for the dams and treated pups
Maternal separation and handling did not affect the body weights of the dams and pups or the average litter size measured at weaning. The average number of days until acquisition of food-reinforced responding in treated adults was not different between groups. The body weights of the dams are given on the 1st (session 1) and the last (session 14) days of self-administration. The body weights of the treated adults are given on the 1st day of food training, the 1st day of saline self-administration (1st Day), and the last day of cocaine self-administration at the highest dose tested (Last Day). The data are presented as the mean ± S.E.M.
NH | MS0 | MS15 | MS180 | |
|---|---|---|---|---|
| Weaning | ||||
| Body weights (g) | ||||
| Dam weight | 313.9 ± 5.2 | 314.5 ± 8.8 | 312.4 ± 7.5 | 320.6 ± 10.3 |
| Average pup weight | 41.3 ± 1.0 | 42.9 ± 1.1 | 41.4 ± 1.4 | 46.9 ± 2.3 |
| Litter size | 11.9 ± 0.7 | 11.9 ± 0.5 | 12.2 ± 0.3 | 11.4 ± 0.7 |
| Dam self-administration | ||||
| Body weights (g) | ||||
| 1st Day | 285.0 ± 6.5 | 291.4 ± 8.8 | 290.0 ± 7.6 | 298.6 ± 7.4 |
| Last day | 291.1 ± 5.2 | 303.1 ± 9.6 | 302.3 ± 4.5 | 309.9 ± 7.5 |
| MS, handled, and nonhandled adults self-administration | ||||
| Body weights (g) | ||||
| Food training | 410.6 ± 7.5 | 428.7 ± 7.5 | 429.5 ± 11.8 | 444.0 ± 5.4 |
| 1st Day | 403.8 ± 5.4 | 421.3 ± 7.7 | 412.8 ± 6.8 | 434.3 ± 6.5* |
| Last day | 510.5 ± 10.4 | 533.2 ± 9.9 | 530.5 ± 16.1 | 555.8 ± 13.4 |
| Days until food criteria are met | 6.0 ± 0.8 | 6.7 ± 0.6 | 8.3 ± 0.8 | 5.6 ± 0.7 |
↵* p < 0.05 vs. NH.