Determination of the effects of l-t-C6-Pyr-Cer on the blood counts, levels of enzymes, and electrolytes in serum in vivo
The blood counts, levels of serum enzymes, and electrolytes in response to l-t-C6-Pyr-Cer (Pyr-Cer) alone or in combination with GMZ in SCID mice were analyzed by Anilytics, Inc., as described under Materials and Methods. Pyridinium ceramide did not have any detectable effects on these parameters, which were within the normal levels (ranges) in these animals. The data shown here represent the blood work of one of the animals from each group.
Treatment | RBC | Hemoglobin | BUN | Creatinine | Na | Mg | ALT | Amylase | |
|---|---|---|---|---|---|---|---|---|---|
| 1 × 106 cells/ml | g/100 ml | mg/100 ml | mM/l | U/l | |||||
| Control | 8.0 | 13.9 | 19 | 0.4 | 145 | 3.1 | 24 | 763 | |
| Pyr-Cer | 8.4 | 14.1 | 23 | 0.6 | 142 | 2.7 | 52 | 1589 | |
| GMZ/Cer | N.D. | N.D. | 36 | 0.5 | 147 | 3.1 | 23 | 1526 | |
RBC, red blood cell; BUN, blood urea nitrogen; ALT, alanine aminotransferase; N.D., not determined.