Parameter | Control | 0.1 μM (n = 4) | 0.2 μM (n = 7) | 1 μM (n = 7) | Wash (n = 6) |
---|---|---|---|---|---|
RMP (mV) | -84.3 ± 2.36 (n = 14) | -88.45 ± 5.02 | -83.84 ± 1.18 | -85.03 ± 1.92 | -84.5 ± 1.23 |
APA (mV) | 118.33 ± 3.00 (n = 14) | 0.18 ± 1.39a | 3.11 ± 0.96a | 2.78 ± 2.02a | 0.36 ± 1.97a |
APD90 (ms) | 212.66 ± 34.76 (n = 14) | 11.22 ± 12.23a | 49.28 ± 16.31*a | 49.43 ± 8.18*a | 15.80 ± 4.42a |
APD50 (ms) | 94.14 ± 20.45 (n = 14) | 25.04 ± 18.83a | 117.58 ± 34.69*a | 114.81 ± 27.58*a | 23.43 ± 12.45a |
APA @ 50 ms | 72.26 ± 5.32 (n = 10) | 15.36 ± 13.24a | 53.25 ± 9.34*a | 59.28 ± 7.88*a | 21.63 ± 9.62a |