TABLE 1
Fundamental reactions of Hb with NOx
Hemoglobin Reactions with Nitrogen Species | Kinetic | References |
|---|---|---|
| DeoxyHb | ||
| 1. HbFe(II) + NO → (NO)HbFe(II) | Fast | |
| 2. HbFe(II) + HNO → → (NO)HbFe(II) | Multistep | Sulc et al., 2004 |
3.  | Fast | Doyle et al., 1981; Sulc et al., 2004 |
| 4. HbFe(II) (deoxy Hb) + GSNO → HbFe(III) + NO + GSH | Slow | Spencer et al., 2000 |
| MetHb | ||
| 5. HbFe(III) + NO → → (NO)HbFe(II) | Slow, multistep | Hoshino et al., 1996 |
| 6. HbFe(III) + HNO → (NO)HbFe(II) | Fast | Doyle et al., 1981 |
| OxyHb | ||
7.  | Pawloski et al., 2001 | |
8.  | Wink et al., 2003 | |
9.  | Slow, multistep |
|