Mean transit times of noneliminated reference indicators and their distribution volumes obtained with superposition and splining procedures for M3G in multiple indicator dilution (MID) studies in the perfused rat liver
M3G | Q | Dose in Bile | Transit Time | Distribution Space | t0 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RBC | Albumin | Sucrose | Water | M3G | Sinusoidal Blood Volume | Plasma Space | Albumin Disse Space | Sucrose Disse Space | Cellular Water Space | ||||||||||||
| ml/min/g | % | s | ml/g liver | s | |||||||||||||||||
| 10 μM | 0.98 | 3.02 | 18.0 | 24.4 | 27.4 | 73.8 | 27.4 | 0.20 | 0.17 | 0.09 | 0.13 | 0.69 | 5.7 | ||||||||
| 45 μM | 0.97 | 2.50 | 17.5 | 20.9 | 20.4 | 67.6 | 22.8 | 0.26 | 0.22 | 0.04 | 0.04 | 0.69 | 1.5 | ||||||||
| 52 μM | 1.22 | 1.70 | 18.9 | 23.3 | 23.6 | 67.6 | 25.9 | 0.32 | 0.27 | 0.08 | 0.08 | 0.82 | 3.4 | ||||||||
| 107 μM | 0.87 | 3.45 | 14.6 | 19.2 | 23.5 | 59.5 | 21.1 | 0.17 | 0.14 | 0.06 | 0.11 | 0.49 | 3.0 | ||||||||
| 115 μM | 1.45 | 3.47 | 9.3 | 12.0 | 14.5 | 39.4 | 13.8 | 0.20 | 0.17 | 0.06 | 0.11 | 0.55 | 1.0 | ||||||||
| 216 μM | 1.02 | 6.00 | 11.3 | 14.8 | 17.6 | 55.9 | 24.3 | 0.14 | 0.11 | 0.05 | 0.09 | 0.60 | 3.4 | ||||||||
| 262 μM | 1.08 | 6.40 | 17.0 | 23.1 | 25.9 | 57.9 | 27.4 | 0.24 | 0.20 | 0.09 | 0.13 | 0.53 | 3.7 | ||||||||
| Mean | 1.08a | 3.69 | 15.2 | 19.7 | 22.2 | 60.7 | 23.5 | 0.22 | 0.18 | 0.07 | 0.11 | 0.63 | 3.1 | ||||||||
| S.D. | 0.18 | 1.65 | 3.4 | 4.3 | 4.4 | 10.5 | 4.5 | 0.06 | 0.05 | 0.02 | 0.04 | 0.11 | 1.4 | ||||||||
↵ a Equivalent to 0.018 ± 0.003 ml s–1 g–1