TABLE 1

Blood gas analysis before and after MCAO; pH, PO2, and PCO2 were measured before and 45 and 90 min post-MCAO Values are the mean ± S.D. for five rats/group.

Group
Saline
SOV
12.5 mM
25 mM
37.5 mM
50 mM
Pre-MCAO
   pH 7.42 ± 0.04 7.43 ± 0.04 7.41 ± 0.07 7.43 ± 0.05 7.41 ± 0.06
   PCO2 (mm Hg) 44 ± 6 42 ± 6 44 ± 6 44 ± 6 46 ± 6
   PO2 (mm Hg) 150 ± 36 148 ± 37 145 ± 26 150 ± 31 145 ± 34
45 Min post-MCAO
   pH 7.44 ± 0.02 7.44 ± 0.01 7.42 ± 0.03 7.39 ± 0.04 7.32 ± 0.02**
   PCO2 (mm Hg) 43 ± 1 41 ± 5 46 ± 2 49 ± 6 47 ± 4
   PO2 (mm Hg) 155 ± 9 156 ± 38 162 ± 9 163 ± 14 175 ± 10*
90 Min post-MCAO
   pH 7.47 ± 0.01† 7.44 ± 0.07 7.44 ± 0.05 7.41 ± 0.05 7.33 ± 0.04**
   PCO2 (mm Hg) 39 ± 2 39 ± 10 42 ± 6 45 ± 5 49 ± 4**
   PO2 (mm Hg)
147 ± 5
160 ± 10**
168 ± 5**
174 ± 5**
182 ± 7**,†

  • ↵* p < 0.05

  • ↵** p < 0.01 controls vs. SOV group

  • ↵† p < 0.05

  • ↵†† p < 0.01 vs. pre-MCAO