Functional properties for the β2 adrenoceptor agonists at the human β adrenoceptors Data are expressed as mean ± S.E.M. of n different experiments.
Agonist | β1 | β2 | β3 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | pEC50 | Emax (% isoprenaline) | n | pEC50 | Emax (% isoprenaline) | n | pEC50 | Emax (% isoprenaline) | |||||||
| Isoprenaline | 12 | 7.46 ± 0.05 | 99 ± 2 | 10 | 7.22 ± 0.01 | 98 ± 1 | 8 | 7.91 ± 0.07 | 99 ± 2 | ||||||
| Indacaterol | 5 | 6.60 ± 0.24 | 16 ± 2 | 5 | 8.06 ± 0.02 | 73 ± 1 | 4 | 6.72 ± 0.13 | 113 ± 7 | ||||||
| Formoterol | 5 | 6.96 ± 0.12 | 29 ± 2 | 5 | 8.58 ± 0.02 | 90 ± 1 | 4 | 7.56 ± 0.14 | 103.0 ± 4.7 | ||||||
| Salmeterol | 5 | 7.17 ± 0.85 | –11 ± 2 | 5 | 9.15 ± 0.05 | 38 ± 1 | 4 | 6.03 ± 0.05 | 59 ± 2 | ||||||
| Salbutamol | 5 | 5.93 ± 0.44 | –3 ± 1 | 5 | 6.60 ± 0.02 | 47 ± 1 | 4 | 5.74 ± 0.09 | 99 ± 6 | ||||||