Urine chemistry parameters of wild-type and Mrp2–/– mice
The parameters tested were normalized to urine volume (milliliters).
Data represent means ± S.E. determined from urine samples obtained from five groups of animals: each group included three animals as described under Materials and Methods.
Parameter | Males | Females | ||||
|---|---|---|---|---|---|---|
| Wild Type | Mrp2-/- | Wild Type | Mrp2-/- | |||
| Glucose (mg/dl/ml) | 3.6 ± 1.6 | 4.0 ± 1.1 | 2.1 ± 0.4 | 3.8 ± 1.0 | ||
| Urea nitrogen (mg/dl/ml) | 496 ± 223 | 508 ± 145 | 252 ± 49 | 415 ± 110 | ||
| Creatinine (mg/dl/ml) | 8.7 ± 4.0 | 9.4 ± 2.4 | 3.8 ± 0.6 | 6.5 ± 1.7 | ||
| Total protein (g/dl/ml) | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.04 ± 0.01 | 0.1 ± 0.01 | ||
| Total bilirubin (mg/dl/ml) | 0.7 ± 0.3 | 0.7 ± 0.2 | 0.4 ± 0.1 | 0.7 ± 0.2 | ||
| Direct bilirubin (mg/dl/ml) | 0.06 ± 0.01 | 0.4* ± 0.1 | 0.03 ± 0.003 | 0.2* ± 0.04 | ||
| Phosphorus (mg/dl/ml) | 36.2 ± 14.2 | 39.1 ± 9.3 | 21.2 ± 3.4 | 29.8 ± 6.8 | ||
| Sodium (mEq/l/ml) | 19.4 ± 5.0 | 19.4 ± 4.8 | 11.2 ± 1.7 | 16.1 ± 4.1 | ||
| Potassium (mEq/l/ml) | 52.7 ± 25.8 | 52.4 ± 15.2 | 21.1 ± 5.2 | 36.4 ± 9.8 | ||
| Chloride (mEq/l/ml) | 17.0 ± 4.3 | 16.8 ± 4.3 | 10.9 ± 1.9 | 16.3 ± 4.5 | ||
↵* P < 0.05, significantly different from wild-type mice.