Serum chemistry parameters of wild-type and Mrp2–/– mice
Data represent means ± S.E. determined from five to six animals.
Parameter | Males | Females | ||||
|---|---|---|---|---|---|---|
| Wild Type | Mrp2-/- | Wild Type | Mrp2-/- | |||
| Glucose (mg/dl) | 128 ± 10 | 145 ± 21 | 139 ± 6 | 119 ± 9 | ||
| Urea nitrogen (mg/dl) | 26.1 ± 1.5 | 30 ± 2.9 | 25.0 ± 2.8 | 19.8 ± 1.8 | ||
| Total protein (g/dl) | 6.2 ± 0.2 | 6.0 ± 0.1 | 5.7 ± 0.1 | 6.1 ± 0.04 | ||
| Albumin (g/dl) | 4.1 ± 0.2 | 4.1 ± 0.1 | 4.3 ± 0.1 | 4.5 ± 0.1 | ||
| Total bilirubin (mg/dl) | 0.1 ± 0.02 | 0.5** ± 0.02 | 0.1 ± 0.02 | 0.5** ± 0.1 | ||
| Direct bilirubin (mg/dl) | <0.1a | 0.3 ± 0.02 | <0.1a | 0.3 ± 0.03 | ||
| Alkaline phosphatase (U/l) | 89.2 ± 5.0 | 81.8 ± 8.7 | 183 ± 14 | 132** ± 15 | ||
| Alanine aminotransferase (U/l) | 40.3 ± 5.4 | 34.7 ± 3.8 | 56.6 ± 10.1 | 36.8 ± 5.4 | ||
| Aspartate aminotransferase (U/l) | 234 ± 41 | 164 ± 42 | 217 ± 45 | 142 ± 20 | ||
| Lactate dehydrogenase (U/l) | 543 ± 127 | 334 ± 67 | 403 ± 56 | 275 ± 43 | ||
| Cholesterol (mg/dl) | 83.5 ± 8.2 | 130** ± 9 | 80.8 ± 6.4 | 95.2 ± 4.6 | ||
| Calcium (mg/dl) | 10.1 ± 0.1 | 10.3 ± 0.2 | 10.0 ± 0.1 | 10.3 ± 0.1 | ||
| Phosphorus (mg/dl) | 7.5 ± 0.2 | 7.9 ± 0.4 | 7.6 ± 0.7 | 7.3 ± 0.4 | ||
| Sodium (mEq/l) | 154 ± 1 | 155 ± 1 | 154 ± 2 | 154 ± 1 | ||
| Potassium (mEq/l) | 7.6 ± 0.4 | 7.4 ± 0.2 | 7.5 ± 0.3 | 6.9 ± 0.5 | ||
| Chloride (mEq/l) | 114 ± 1 | 114 ± 1 | 113 ± 2 | 111 ± 1 | ||
| Triglycerides (mg/dl) | 62.8 ± 5.3 | 75.0 ± 9.2 | 62.2 ± 8.4 | 64.6 ± 3.8 | ||
| Creatine kinase (U/l) | 676 ± 101 | 661 ± 197 | 484 ± 63 | 430 ± 152 | ||
| Magnesium (mg/dl) | 2.7 ± 0.1 | 2.7 ± 0.2 | 2.8 ± 0.2 | 2.8 ± 0.2 | ||
| Osmolality (mOsmol/kg) | 304 ± 5 | 316 ± 1 | 309 ± 3 | 309 ± 2 | ||