TABLE 1

Clozapine increases the activity of TH and AAAD in the striatum of the MPTP mouse

Mice were treated with 30 mg/kg i.p. MPTP or saline daily for 7 days and 24 h later with a single dose of 20 mg/kg i.p. clozapine or vehicle and killed at the indicated times. TH and AAAD activities were estimated in striatum as described under Materials and Methods.

Treatment
TH
AAAD
nmol / mg protein / 20 min ± S.E.M.
Saline 0.95 ± 0.03 37 ± 2
    Clozapine, 30 min 1.3 ± 0.07* 51 ± 5*
    Clozapine, 60 min 1.3 ± 0.09* 54 ± 3*
MPTP 0.32 ± 0.02 16 ± 1*
    Clozapine, 30 min 0.60 ± 0.03** 24 ± 4**
    Clozapine, 60 min
0.50 ± 0.02**
25 ± 3**

  • ↵* p < 0.05 compared with the saline-treated group.

  • ↵** p < 0.05 compared with the MPTP- treated group, n = 8.