Treatment | DA | DOPAC | HVA | DOPAC + HVA/DA | ||
---|---|---|---|---|---|---|
pmol / mg protein ± S.E.M. | ||||||
Saline | 464 ± 15 | 70 ± 9 | 50 ± 2 | 0.25 | ||
MPTP | 116 ± 16* | 23 ± 2* | 21 ± 2* | 0.38 | ||
Control + l-DOPA | 544 ± 12** | 160 ± 2** | 108 ± 5** | 0.49 | ||
MPTP + l-DOPA | 228 ± 12** | 145 ± 20** | 123 ± 14** | 1.17 | ||
Saline + clozapine | 580 ± 48** | 147 ± 9** | 78 ± 4** | 0.39 | ||
MPTP + clozapine | 246 ± 21 | 62 ± 5** | 45 ± 5** | 0.43 | ||
Saline + clozapine + l-DOPA | 567 ± 39 | 432 ± 51*** | 172 ± 6*** | 1.06 | ||
MPTP + clozapine + l-DOPA | 279 ± 11 | 402 ± 60*** | 243 ± 31*** | 2.31 |