Aorta Rmax | G0 Rmax | ||
---|---|---|---|
% relaxation | |||
Vehicle (0.1% EtOH; 2 h) | 59.0 ± 4.4 | 99.2 ± 7.4 | |
THC (10 μM; 2 h) | 66.9 ± 4.6 | 130 ± 12* | |
Vehicle (0.1% EtOH; 10 min) | 68.9 ± 4.1 | 89.8 ± 6.3 | |
THC (10 μM; 10 min) | 62.0 ± 4.2 | 93.9 ± 10.1 | |
Vehicle and l-NAME (300 μM) | 3.29 ± 1.2 | 14.6 ± 1.5 | |
THC and l-NAME (300 μM) | 4.73 ± 2.0 | 35.1 ± 2.5** | |
Vehicle and GW9662 (1 μM) | 45.9 ± 5.9 | 74.7 ± 6.9 | |
THC and GW9662 (1 μM) | 44.8 ± 4.4 | 79.4 ± 8.9 | |
Vehicle and catalase (2500 U/ml) | 62.9 ± 13.9 | 75.0 ± 4.6 | |
THC and catalase (2500 U/ml) | 60.4 ± 15.9 | 83.1 ± 5.7 | |
Vehicle and DETCA (3 mM) | 56.3 ± 6.9 | 94.4 ± 11.3 | |
THC and DETCA (3 mM) | 64.2 ± 4.6 | 108 ± 16 |
Asterisk (*) denotes a significant augmentation of the maximal vasorelaxant response in THC-treated vessels (10 μM) compared with vehicle-treated (0.1% EtOH) vessels (*P < 0.05, **P < 0.01).