TABLE 1

Effect of continuous infusion of thiorphan into the hippocampus on endogenous Aβ40 and Aβ42 in rats

Values are the means ± S.E.M. for four to five animals. The rats were decapitated on day 27 after the start of thiorphan infusion, and the amounts of Aβ40 and Aβ42 in discrete brain regions were determined. Results with one-way ANOVA on Aβ40 and Aβ42 levels in the hippocampus were as follows: soluble Aβ: Aβ40, F(2,12) = 2.04, p = 0.17; Aβ42, F(2,12) = 3.06, p = 0.08; insoluble Aβ: Aβ40, F(2,11) = 20.48, p < 0.01; Aβ42, F(2,11) = 7.04, p < 0.05; total Aβ: Aβ40, F(2,11) = 19.31, p < 0.01; Aβ42, F(2,11) = 6.05, p < 0.05.

Aβ40
Aβ42
pmol/g wet wt.
Soluble Aβ
    Veh/SAL 0.095 ± 0.002 0.093 ± 0.008
    Thio/SAL 0.087 ± 0.004 0.079 ± 0.002
    Thio/NAL 0.089 ± 0.003 0.077 ± 0.002
Insoluble Aβ
    Veh/SAL 0.409 ± 0.018 0.321 ± 0.036
    Thio/SAL 0.746 ± 0.035** 0.466 ± 0.020**
    Thio/NAL 0.688 ± 0.061** 0.455 ± 0.036*
Total Aβ
    Veh/SAL 0.504 ± 0.017 0.414 ± 0.035
    Thio/SAL 0.832 ± 0.036** 0.545 ± 0.019**
    Thio/NAL
0.802 ± 0.070**
0.531 ± 0.035**

  • ↵* p < 0.05; ** p < 0.01 compared with Veh/SAL-treated rats.