Effects of ODQ and methylene blue on pIC50 and Emax values for NTG, NOR 3, and ANP in rat aorta and mesenteric artery
Numbers in parentheses represent number of experiments.
Control | ODQ (10-5 M) | Methylene Blue (10-5 M) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| pIC50 | Emax | pIC50 | Emax | pIC50 | Emax | |||||
| % | % | |||||||||
| NTG | Aorta | 7.75 ± 0.16 (5) | 98.6 ± 0.8 (5) | <5.0 (5) | 7.1 ± 1.1** (5) | |||||
| 7.69 ± 0.15 (4) | 104.6 ± 1.2 (4) | 5.51 ± 0.15** (4) | 69.8 ± 6.0* (4) | |||||||
| Mesenteric artery | 7.64 ± 0.26 (4) | 94.5 ± 3.6 (4) | <5.0 (4) | 0.2 ± 1.7** (4) | ||||||
| 7.57 ± 0.20 (3) | 96.5 ± 0.7 (3) | <5.0 (3) | 26.7 ± 3.5** (3) | |||||||
| NOR 3 | Aorta | 7.74 ± 0.13 (4) | 99.6 ± 1.3 (4) | <6.0 (4) | 1.0 ± 0.6** (4) | |||||
| Mesenteric artery | 7.26 ± 0.08 (4) | 98.1 ± 2.3 (4) | <6.0 (4) | 1.8 ± 2.1** (4) | ||||||
| ANP | Aorta | 8.42 ± 0.08 (4) | 102.5 ± 1.1 (4) | 8.60 ± 0.10 (4) | 99.5 ± 0.8 (4) | |||||
|
| Mesenteric artery | 8.01 ± 0.17 (3) | 90.5 ± 5.0 (3) |
|
| 8.18 ± 0.12 (3) | 92.5 ± 6.8 (3) | |||
↵* P < 0.05, ** P < 0.01, significant differences between two groups.