TABLE 3

Mean heart rate and mean arterial blood pressure at baseline and for 4 h after administration of rotigaptide in a canine model of ischemia/reperfusion injury

Values represent means ± S.E.M. for n = 5–8 dogs per group.

Treatment
Baseline
1 h
2 h
3 h
4 h
Mean heart rate
    Saline control 151 ± 9 128 ± 5 144 ± 10 152 ± 6 159 ± 6
    1 ng/kg bolus + 10 ng/kg/h rotigaptide 160 ± 6 151 ± 15 168 ± 9 179 ± 9 178 ± 8
    10 ng/kg bolus + 100 ng/kg/h rotigaptide 178 ± 22 154 ± 9 178 ± 10 172 ± 7 161 ± 7
    100 ng/kg bolus + 1000 ng/kg/h rotigaptide 160 ± 9 156 ± 12 169 ± 12 172 ± 9 170 ± 7
    1000 ng/kg bolus + 10 μg/kg/h rotigaptide 157 ± 10 146 ± 8 157 ± 5 163 ± 6 165 ± 6
Mean arterial blood pressure
    Saline control 99 ± 7 84 ± 9 88 ± 9 87 ± 9 89 ± 9
    1 ng/kg bolus + 10 ng/kg/h rotigaptide 98 ± 6 79 ± 3 87 ± 3 87 ± 3 84 ± 3
    10 ng/kg bolus + 100 ng/kg/h rotigaptide 103 ± 6 93 ± 8 93 ± 6 90 ± 5 82 ± 6
    100 ng/kg bolus + 1000 ng/kg/h rotigaptide 90 ± 5 85 ± 7 85 ± 4 88 ± 4 87 ± 4
    1000 ng/kg bolus + 10 μg/kg/h rotigaptide
81 ± 10
79 ± 7
77 ± 9
82 ± 8
78 ± 8