TABLE 3
NAMI-A distribution in the primary and metastatic B16 melanoma cells following in vivo treatment.
Ruthenium uptake was measured on 1 × 106 cells of the primary tumor mass harvested from three different mice 24 h after the end of the treatment (day 18) with 35 mg/kg/day NAMI-A for 6 consecutive days (days 12–17 after tumor implantation). Ruthenium uptake from lung metastases was conversely measured using fragments of lung metastases collected at sacrifice (day 35) from three different mice that were treated with 35 mg/kg/day for 6 consecutive days, on days 10 to 15 (before surgery) or on days 17 to 22 (after surgery).