Population parameter estimates for the description of the circadian rhythm in body temperature baseline and the temperature profile after vehicle treatment
Intraindividual variability was <1%.
Parameter | Unit | Estimate ± S.E. | Interindividual Variability (%) |
|---|---|---|---|
| α | h-1 | 0.90 ± 0.06 | |
| β | h-1 | 0.66 ± 0.06 | |
| T ref | °C | 37.2 ± 0.02 | <1 |
| amp | 0.04 ± 0.01 | 11 | |
| D | 0.06 ± 0.01 | ||
| k HD | h-1 | 1.8 ± 0.6 | |
| P (pump) | 0.004 ± 0.004 | 146 | |
| P (injection) |
| 0.03 ± 0.01 | 62 |