Estimated and fixed parameters for receptor dynamics
Parameter (units) | Definition | Estimate | CV% |
|---|---|---|---|
| ks,Rm (fmol/g lung/h) | Zero-order input of receptor message | 0.13 | 12 |
| Tinf (h) | Duration of receptor message input | 40.3 | 12 |
| kd,Rm (h-1) | First-order rate of receptor mRNA degradation | 0.0067 | 26 |
| τR (h) | Receptor transit time | 71.8 | 33 |
| γr | Amplification factor for the translation of receptor message to protein | 2.98 | 3 |
| Kd,cort (nM) | Equilibrium dissociation constant for corticosterone | 22.1 | Fixed |
| Kd,DEX (nM) | Equilibrium dissociation constant for dexamethasone | 4.70 | Fixed |
| mRNAR0 (fmol/g lung) | Average receptor message observed at time 0 (gestational day 17) | 4.13 | Fixed |
| R0total (fmol/mg protein) | Receptor baseline value | 326 | Fixed |