The superoxide scavenger tempol abrogates the effect of TNFα on glomerular albumin permeability (Palb)
Each group represent mean values ± S.E.M.; n = 15 observations made in glomeruli isolated from three rats in each group (glomeruli were selected from each rat).
| Group | Palb ± S.E.M. |
|---|---|
| Untreated control | 0.002 ± 0.08 (15 glomeruli from three rats) |
| TNFα (4 ng/ml) | 0.81 ± 0.12 (P < 0.001 vs. control) |
| TNFα (4 ng/ml) + tempol (2 mM) | 0.31 ± 0.13 (P < 0.001 vs. control; P < 0.005 vs. TNFα) |
| TNFα (4 ng/ml) + tempol (5 mM) | -0.027 ± 0.065 (not significant vs. control) |
| Tempol (5 mM) | 0.027 ± 0.1 (not significant vs. control) |