EC50, maximal effect (Emax), and time to achieve Emax of putative neurotransmitters on porcine LES
Results are expressed in percent decrease (–) or increase (+) of active resting tone.
| Agonist | EC50 | Emax | Time to Emax |
|---|---|---|---|
| % | s | ||
| SNP | 61.2 nM | -92.1 ± 6.3% | 83.51 ± 6.34 |
| VIP | 52.3 nM | -47.1 ± 12.2% | 161.01 ± 12.84 |
| CORM-1 | 120.2 μM | -30.94 ± 6.7% | 103.08 ± 12.28 |
| ATP (FR) | 133.6 μM | -96.0 ± 12% | 9.73 ± 0.50* |
| ATP (SR) | 606.7 μM | -86.2 ± 19% | 148.03 ± 25.18 |
| ATP (FC) | 27.9 μM | +20.7 ± 11.7% | 11.65 ± 1.27* |
| PACAP (FR) | 81.1 nM | -98.0 ± 4.7% | 24.91 ± 3.68* |
| PACAP (SR) | 20.1 nM | -112.9 ± 11% | 119.26 ± 16.19 |
| CGRP | 0% |
FR, fast relaxation; FC, fast contraction; SR, slow relaxation.
↵* , p < 0.05, fast responses.