Catalytic activity (means ± S.D.) of hepatic CYP3A (S-9 fractions of livers harvested from FVB pregnant and nonpregnant mice after oral administration of NFV) as measured by testosterone 6β-hydroxylation
| Parameter | Pregnant Mice (n = 4) | Nonpregnant Mice (n = 4) | p Valuea |
|---|---|---|---|
| 6β-Hydroxytestosterone (mol/min/mg protein) | 0.12 ± 0.04 | 0.05 ± 0.02 | 0.0009 |
↵ a Parameters were compared using the two-sample t test (equal variance, statistical significance p < 0.05).