Effect of i.v. insulin (0.1 U/kg/h) or GLP-1 analog (10 μg/kg/h) for 120 min on plasma hormone levels in glucose infusion-induced acute hyperglycemia
Results are mean ± S.E.M., four to 12 rats.
| Parameters | Hormone Levels | ||
|---|---|---|---|
| Vehicle (n = 12) | GLP-1 (n = 8) | Insulin (n = 4) | |
| Insulin (ng/ml) | 0.25 ± 0.03 | 0.65 ± 0.26* | N.D. |
| GH (ng/dl) | 45.02 ± 11.93 | 18.80 ± 3.04 | 36.20 ± 8.11 |
| Glucagon (pg/ml) | 73.91 ± 6.32 | 81.63 ± 10.82 | 160.25 ± 22.37** |
| Adrenocorticotropic hormone (pg/ml) | 258.27 ± 56.71 | 238.88 ± 23.66 | 237.00 ± 49.69 |
| Corticosterone (ng/ml) | 299.45 ± 19.94 | 345.38 ± 26.88 | 358.50 ± 43.07 |
N.D., not determined.
↵* p < 0.05; ** p < 0.001 vs. vehicle.