TABLE 3

Plasma levels of insulin, glucagon, and resistin

Animal treatments and ELISAs for plasma insulin, glucagon, and resistin are as described under Materials and Methods. Data (nanograms per milliliter) are means ± S.E.M. (n = 5-6).

Peptide Sham Surgery Partial Hepatectomy
- LPS + LPS - LPS + LPS
+ Metformin + Metformin
Insulin 528 ± 72 811 ± 87a 1130 ± 57b 510 ± 68c 637 ± 113a 628 ± 102
Glucagon 271 ± 59 1862 ± 254a 796 ± 129b 297 ± 123c 5251 ± 532a,b 2322 ± 439a,c
Resistin 13.8 ± 1.5 18.6 ± 0.8a 13.7 ± 1.2 11.1 ± 0.9 28.0 ± 2.7a,b 18.4 ± 1.8a,c
  • a P < 0.05 compared with animals injected with saline instead of LPS.

  • b P < 0.05 compared with animals that underwent a sham operation.

  • c P < 0.05 compared with the absence of metformin.