Summary of findings
Enzyme | M2 Pathways | M3 Pathways |
|---|---|---|
| PI-PLC | ET-18-OCH3 decreases carbachol potency | ET-18-OCH3 decreases darifenacin affinity |
| ET-18-OCH3 decreases carbachol potency | ||
| PC-PLC | D609 decreases carbachol maximum | D609 decreases carbachol maximum |
| ROCK | Y-27632 increases darifenacin affinity | HA1077 decreases darifenacin affinity |
| Y-27632 decreases carbachol potency | HA1077 decreases carbachol maximum | |
| HA1077 decreases carbachol maximum | HA1077 decreases carbachol potency | |
| HA1077 decreases carbachol potency | H89 decreases carbachol maximum | |
| H7 increases darifenacin affinity | H89 decreases carbachol potency | |
| H7 decreases carbachol maximum | ||
| H89 decreases carbachol maximum | ||
| H89 decreases carbachol potency | ||
| PKA | H7 increases darifenacin affinity | H89 decreases carbachol maximum |
| H89 decreases carbachol maximum | H89 decreases carbachol potency | |
| H89 decreases carbachol potency | ||
| PKC | Chelerytherine increases darifenacin affinity | |
| H7 increases darifenacin affinity | ||
| PKG | H89 decreases carbachol maximum | H89 decreases carbachol maximum |
|
| H89 decreases carbachol potency | H89 decreases carbachol potency |