Effects of the mGlu2/3 receptor agonist LY354740 or the mGlu2/3 prodrug LY544344 on baseline body temperature (in °C) in the stress-induced hyperthermia model
Data are presented as the mean (±S.E.M.) prestress core body temperature, measured at the end of the 60-min baseline period (i.e., prior to presentation of the stressor) in male DBA/2 mice.
Compound | Dose | n | Prestress Body Temperature |
|---|---|---|---|
| mg/kg | mean ± S.E.M. | ||
| LY354740 (p.o.) | 0 | 8 | 36.20 (0.22) |
| 3 | 7 | 36.23 (0.31) | |
| 10 | 6 | 36.09 (0.18) | |
| 30 | 7 | 36.30 (0.34) | |
| LY544344 (p.o.) | 0 | 6 | 36.02 (0.28) |
| 3 | 6 | 36.92 (0.18) | |
| 10 | 6 | 36.60 (0.14) | |
| 30 | 6 | 37.45 (0.15)* | |
| LY354740 (s.c.) | 0 | 7 | 36.41 (0.23) |
|
| 10 | 7 | 36.58 (0.40) |
↵* Significant difference from vehicle group (p < 0.05).