Cardiac electrophysiologic study in anesthetized rats
Effects of continuous intravenous infusion of DPO-1 (mg/kg/min i.v. × 20 min) on electrocardiographic and cardiac electrophysiologic parameters, measured at baseline and at 20 min after start of continuous infusion. Data are mean ± S.E.M. with n = 4 to 5.
Parameter | DPO-1 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.06 | 0.2 | 0.6 | |||||||||
| Baseline | 20 min | Baseline | 20 min | Baseline | 20 min | ||||||
| MAP (mm Hg) | 84 ± 2 | 87 ± 3 | 89 ± 3 | 92 ± 4 | 90 ± 2 | 101 ± 4* | |||||
| R-R interval (ms) | 227 ± 4 | 234 ± 13 | 230 ± 9 | 216 ± 12 | 233 ± 5 | 259 ± 5 | |||||
| PR interval (ms) | 56 ± 2 | 57 ± 2 | 60 ± 1 | 59 ± 1 | 56 ± 2 | 58 ± 2 | |||||
| AH interval (ms) | 43 ± 2 | 44 ± 2 | 47 ± 2 | 46 ± 1 | 45 ± 2 | 46 ± 2 | |||||
| HV interval (ms) | 7 ± 1 | 7 ± 1 | 8 ± 1 | 7 ± 1 | 9 ± 1 | 8 ± 1 | |||||
| AVRP (ms) | 93 ± 2 | 96 ± 3 | 97 ± 4 | 96 ± 4 | 95 ± 2 | 100 ± 2* | |||||
| ARP (ms) | 52 ± 2 | 58 ± 2* | 50 ± 3 | 62 ± 2* | 45 ± 1 | 64 ± 3* | |||||
| VRP (ms) | 56 ± 2 | 61 ± 2* | 65 ± 1 | 79 ± 3* | 58 ± 2 | 78 ± 2* | |||||
AVRP, atrioventricular nodal refractory period.
↵* p < 0.05 using a paired Student's t test to detect statistically significant changes from appropriate baseline.