[3H]AFDX-384 autoradiography
Areas with densitometry values that were significantly different from age-saline values are also designated with a bold font.
Brain Area | Young Saline | Aged Saline | Low Donepezil | High Donepezil | Low Galantamine | High Galantamine |
|---|---|---|---|---|---|---|
| Telencephalon | ||||||
| Neocortex | ||||||
| Cortex, cerebral | 2.095 ± 0.076 | 2.050 ± 0.031 | 2.196 ± 0.081 | 2.143 ± 0.069 | 2.171 ± 0.079 | 2.071 ± 0.084 |
| Lamina I-IV | 2.112 ± 0.078 | 2.048 ± 0.016 | 2.236 ± 0.084* | 2.195 ± 0.053 | 2.223 ± 0.066* | 2.116 ± 0.071 |
| Lamina VI | 2.061 ± 0.112 | 2.170 ± 0.033 | 2.162 ± 0.109 | 2.121 ± 0.079 | 2.150 ± 0.090 | 2.061 ± 0.096 |
| Entorhinal | 1.793 ± 0.084 | 1.873 ± 0.026 | 1.883 ± 0.102 | 1.833 ± 0.069 | 1.929 ± 0.106 | 1.738 ± 0.082 |
| Piriform | 2.220 ± 0.354 | 1.802 ± 0.036 | 1.974 ± 0.085* | 1.879 ± 0.051 | 1.950 ± 0.063 | 1.824 ± 0.073 |
| Rhinencephalon | ||||||
| Olfactory Complex | ||||||
| Anterior olfactory N. | 2.096 ± 0.044 | 2.029 ± 0.055 | 2.215 ± 0.056* | 2.142 ± 0.052 | 2.229 ± 0.043 | 2.124 ± 0.063 |
| Olfactory bulb | ||||||
| External plexiform layer | 2.569 ± 0.120 | 2.350 ± 0.084 | 2.776 ± 0.082** | 2.631 ± 0.041* | 2.716 ± 0.131** | 2.694 ± 0.105** |
| Internal plexiform layer | 2.117 ± 0.136 | 2.079 ± 0.034 | 2.352 ± 0.100* | 2.198 ± 0.107 | 2.236 ± 0.103 | 2.153 ± 0.102 |
| Olfactory tubercle | 2.573 ± 0.042 | 2.624 ± 0.075 | 2.763 ± 0.069 | 2.634 ± 0.051 | 2.747 ± 0.047 | 2.611 ± 0.084 |
| Hippocampus proper | ||||||
| CA1 | ||||||
| Dorsal | 2.121 ± 0.066 | 2.009 ± 0.033 | 2.212 ± 0.064* | 2.126 ± 0.075 | 2.177 ± 0.067* | 2.127 ± 0.067 |
| Lateral | 2.039 ± 0.073 | 2.026 ± 0.030 | 2.145 ± 0.096 | 2.090 ± 0.074 | 2.160 ± 0.088 | 1.974 ± 0.094 |
| CA2/3 | ||||||
| Dorsal | 1.655 ± 0.104 | 1.634 ± 0.035 | 1.733 ± 0.105 | 1.685 ± 0.070 | 1.690 ± 0.080 | 1.640 ± 0.085 |
| Lateral | 1.543 ± 0.107 | 1.731 ± 0.073 | 1.668 ± 0.125 | 1.576 ± 0.111 | 1.713 ± 0.085 | 1.440 ± 0.132 |
| Dentate Gyrus | ||||||
| Dorsal | 1.877 ± 0.072 | 1.754 ± 0.028 | 1.929 ± 0.064* | 1.878 ± 0.065 | 1.909 ± 0.065 | 1.798 ± 0.082 |
| Lateral | 1.770 ± 0.080 | 1.794 ± 0.030 | 1.852 ± 0.083 | 1.819 ± 0.074 | 1.908 ± 0.074 | 1.691 ± 0.088 |
| Subicular Complex | ||||||
| Subiculum | 1.818 ± 0.117 | 1.925 ± 0.043 | 1.845 ± 0.120 | 1.828 ± 0.097 | 1.857 ± 0.104 | 1.778 ± 0.104 |
| Amygdala | ||||||
| Amygdaloid N. | 1.829 ± 0.119 | 1.884 ± 0.054 | 1.901 ± 0.116 | 1.985 ± 0.044 | 1.939 ± 0.108 | 1.814 ± 0.046 |
| Subcortical nuclear masses | ||||||
| Basal N. | 1.425 ± 0.110 | 1.456 ± 0.098 | 1.500 ± 0.109 | 1.471 ± 0.099 | 1.500 ± 0.126 | 1.419 ± 0.140 |
| Diencephalon | ||||||
| Thalamus | ||||||
| Thalamic N. anterior | 2.170 ± 0.115 | 2.236 ± 0.077 | 2.250 ± 0.117 | 2.246 ± 0.102 | 2.198 ± 0.145 | 2.214 ± 0.155 |
| Mesencephalon | ||||||
| Pons | ||||||
| Pontine N. | 1.555 ± 0.105 | 1.772 ± 0.078 | 1.719 ± 0.111 | 1.657 ± 0.109 | 1.777 ± 0.126 | 1.622 ± 0.167 |
*p < 0.01,**p < 0.001 compared with aged saline controls.