Brain Area | Young Saline | Aged Saline | Low Donepezil | High Donepezil | Low Galantamine | High Galantamine |
---|---|---|---|---|---|---|
Telencephalon | ||||||
Neocortex | ||||||
Cerebral cortex | 10.722 ± 0.285 | 10.397 ± 0.252 | 10.955 ± 0.107 | 10.975 ± 0.152 | 11.021 ± 0.100 | 10.727 ± 0.112 |
Lamina I | ||||||
Lateral | 11.188 ± 0.233 | 10.755 ± 0.334 | 11.017 ± 0.204 | 11.216 ± 0.199 | 11.232 ± 0.155 | 11.085 ± 0.080 |
Medial | 11.504 ± 0.245 | 10.849 ± 0.236 | 11.750 ± 0.131 | 11.828 ± 0.165 | 11.570 ± 0.150 | 11.350 ± 0.128 |
Lamina II | ||||||
Lateral | 9.941 ± 0.188 | 10.135 ± 0.216 | 9.741 ± 0.225 | 10.105 ± 0.120 | 10.115 ± 0.115 | 9.716 ± 0.139 |
Medial | 10.795 ± 0.354 | 8.845 ± 1.744 | 10.684 ± 0.057** | 10.940 ± 0.090** | 10.680 ± 0.076** | 10.276 ± 0.134** |
Entorhinal | 9.995 ± 0.290 | 9.805 ± 0.336 | 9.975 ± 0.198 | 10.184 ± 0.155 | 10.463 ± 0.142 | 10.242 ± 0.134 |
Prefrontal | 11.277 ± 0.184 | 10.810 ± 0.150 | 11.446 ± 0.118 | 11.414 ± 0.157 | 11.381 ± 0.079 | 11.133 ± 0.122 |
Retrosplenial | 10.832 ± 0.362 | 10.445 ± 0.330 | 11.540 ± 0.143 | 11.224 ± 0.171 | 11.321 ± 0.198 | 11.290 ± 0.116 |
Rhinencephalon | ||||||
Olfactory complex | ||||||
Anterior olfactory N. | 11.705 ± 0.188 | 11.278 ± 0.128 | 11.924 ± 0.131 | 11.977 ± 0.155 | 11.960 ± 0.077 | 11.832 ± 0.087 |
Olfactory bulbs | 8.275 ± 0.286 | 6.718 ± 0.702 | 8.982 ± 0.368** | 8.782 ± 0.214* | 8.457 ± 0.572** | 8.338 ± 0.372** |
Olfactory tubercle | 11.624 ± 0.192 | 11.341 ± 0.193 | 11.780 ± 0.126 | 11.978 ± 0.197 | 12.015 ± 0.130 | 11.773 ± 0.130 |
Hippocampus proper | ||||||
CA1 region | 12.985 ± 0.170 | 12.736 ± 0.175 | 13.253 ± 0.108 | 13.181 ± 0.142 | 13.165 ± 0.091 | 13.080 ± 0.132 |
CA2 region | 9.866 ± 0.132 | 10.113 ± 0.170 | 9.713 ± 0.282 | 10.337 ± 0.185 | 10.296 ± 0.182 | 10.048 ± 0.109 |
CA2/3 region | 10.305 ± 0.277 | 10.469 ± 0.185 | 10.510 ± 0.094 | 10.640 ± 0.136 | 10.803 ± 0.116 | 10.428 ± 0.095 |
CA3 region | 10.224 ± 0.195 | 10.054 ± 0.168 | 10.196 ± 0.169 | 10.586 ± 0.185 | 10.396 ± 0.176 | 10.243 ± 0.108 |
Dentate gyrus | 12.596 ± 0.208 | 12.243 ± 0.184 | 12.633 ± 0.300 | 12.923 ± 0.134 | 12.936 ± 0.143 | 12.234 ± 0.350 |
Polymorph layer | 11.129 ± 0.158 | 10.736 ± 0.164 | 11.247 ± 0.106 | 11.332 ± 0.189 | 11.339 ± 0.184 | 11.174 ± 0.115 |
Subicular complex | ||||||
Subiculum | 7.571 ± 0.263 | 7.512 ± 0.367 | 7.151 ± 0.751 | 7.865 ± 0.231 | 8.094 ± 0.244 | 7.858 ± 0.317 |
Subcortical nuclear masses | ||||||
Basal N. | 5.206 ± 0.655 | 4.485 ± 0.902 | 5.632 ± 0.403 | 5.458 ± 0.683 | 4.027 ± 0.772 | 4.949 ± 0.649 |
*p < 0.01; **p < 0.001 compared with aged saline controls.