[125I]IPH (“Epibatidine”) autoradiography
Areas with densitometry values that were significantly different from age-saline values are also designated with a bold font.
Brain Area | Young Saline | Aged Saline | Low Donepezil | High Donepezil | Low Galantamine | High Galantamine |
|---|---|---|---|---|---|---|
| Telencephalon | ||||||
| Neocortex | ||||||
| Cortex, cerebral | 16.341 ± 0.654 | 14.442 ± 0.334 | 15.626 ± 0.552 | 16.089 ± 0.691 | 15.642 ± 0.680 | 16.321 ± 0.698 |
| Lamina I | 11.214 ± 0.510 | 9.715 ± 0.092 | 10.832 ± 0.438 | 11.022 ± 0.578 | 10.878 ± 0.376 | 11.252 ± 0.489 |
| Lamina II | 20.797 ± 1.199 | 17.998 ± 0.279 | 17.919 ± 1.391 | 19.829 ± 0.980 | 18.701 ± 0.800 | 20.147 ± 1.033 |
| Lamina III-VI | 16.803 ± 0.769 | 14.721 ± 0.266 | 16.685 ± 0.713 | 16.340 ± 0.743 | 16.423 ± 0.660 | 16.709 ± 0.744 |
| Cingulate | 19.604 ± 0.410 | 17.418 ± 0.927 | 20.314 ± 0.900* | 20.894 ± 0.987** | 19.720 ± 0.941 | 20.266 ± 0.760 |
| Entorhinal | 10.289 ± 0.420 | 9.085 ± 0.138 | 10.414 ± 0.389 | 11.009 ± 0.574 | 10.114 ± 0.387 | 10.519 ± 0.441 |
| Prefrontal | 16.500 ± 0.607 | 14.595 ± 0.471 | 15.681 ± 0.552 | 16.100 ± 0.638 | 15.421 ± 0.560 | 16.177 ± 0.821 |
| Retrosplenial | 16.258 ± 0.775 | 15.023 ± 0.604 | 16.566 ± 0.574 | 17.035 ± 0.877 | 15.902 ± 0.805 | 16.358 ± 0.763 |
| Rhinencephalon | ||||||
| Olfactory complex | ||||||
| Anterior olfactory N. | 7.090 ± 0.250 | 6.938 ± 0.298 | 6.829 ± 0.136 | 7.154 ± 0.369 | 6.403 ± 0.288 | 7.008 ± 0.360 |
| Hippocampus proper | ||||||
| Dentate gyrus | 3.131 ± 0.223 | 3.283 ± 0.114 | 3.087 ± 0.239 | 3.280 ± 0.362 | 2.962 ± 0.189 | 3.176 ± 0.243 |
| Molecular layer | 5.718 ± 0.151 | 5.623 ± 0.077 | 5.528 ± 0.212 | 5.848 ± 0.222 | 5.467 ± 0.188 | 6.199 ± 0.223 |
| Subicular complex | ||||||
| Presubiculum | 34.358 ± 1.538** | 29.002 ± 0.629 | 27.934 ± 1.270 | 31.615 ± 2.122 | 29.188 ± 2.087 | 30.694 ± 2.614 |
| Subiculum | 16.807 ± 0.649 | 15.249 ± 0.258 | 15.365 ± 0.513 | 15.953 ± 0.800 | 15.271 ± 0.626 | 15.960 ± 0.619 |
| Postsubiculum | 30.814 ± 1.292 | 26.861 ± 0.578 | 29.796 ± 1.175* | 31.525 ± 1.291** | 28.971 ± 1.738 | 31.965 ± 0.968** |
| Septum | ||||||
| Septal N., mediolateral | 4.731 ± 0.404 | 4.398 ± 0.280 | 4.613 ± 0.236 | 4.692 ± 0.121 | 4.981 ± 0.239 | 4.472 ± 0.184 |
| Septal N., triangular | 12.110 ± 0.827 | 10.639 ± 1.582 | 11.388 ± 0.801 | 12.012 ± 0.831 | 12.503 ± 0.338 | 11.459 ± 0.966 |
| Subcortical nuclear masses | ||||||
| Basal N. | 8.768 ± 0.546 | 7.786 ± 0.303 | 8.289 ± 0.473 | 8.543 ± 0.426 | 9.031 ± 0.473 | 8.631 ± 0.294 |
| Diencephalon | ||||||
| Thalamus | ||||||
| Thalamic N. | ||||||
| Anterior | 61.777 ± 1.760** | 55.813 ± 2.274 | 56.546 ± 1.921 | 58.471 ± 2.956 | 54.972 ± 2.561 | 58.291 ± 3.569 |
| Mediodorsal | 40.573 ± 2.111 | 38.324 ± 2.110 | 37.588 ± 1.205 | 38.203 ± 2.034 | 37.470 ± 1.725 | 37.527 ± 2.276 |
*p < 0.01; **p < 0.001 compared with aged saline controls.