Substrate | Vmax | Km | kcat | kcat/Km |
---|---|---|---|---|
nmol/min/μg | mM | min−1 | ||
3′-l-Phenylalanyl-gemecitabine | 283.52 ± 0.41 | 0.51 ± 0.04 | 365.0 ± 8.2 | 718.3 |
3′-d-Phenylalanyl-gemcitabine | 406.92 ± 0.72 | 0.97 ± 0.08 | 523.9 ± 14.4 | 541.3 |
5′-l-Phenylalanyl-gemcitabine | 3.25 ± 0.03 | 0.17 ± 0.03 | 67.0 ± 0.6 | 386.7 |
5′-d-Phenylalanyl-gemcitabine | 3.19 ± 0.03 | 0.22 ± 0.04 | 65.7 ± 0.7 | 301.6 |
3′-l-Valyl-gemcitabine | 0.35 ± 0.01 | 0.90 ± 0.11 | 7.3 ± 0.3 | 8.1 |
3′-l-Isoleucyl-gemcitabine | 0.24 ± 0.01 | 0.94 ± 0.08 | 5.0 ± 0.1 | 5.3 |
3′-d-Valyl-gemcitabine | 0.32 ± 0.01 | 1.43 ± 0.13 | 6.7 ± 0.2 | 4.7 |
5′-l-Isoleucyl-gemcitabine | 0.09 ± 0.00 | 0.85 ± 0.05 | 2.0 ± 0.0 | 2.3 |
5′-d-Valyl-gemcitabine | 0.13 ± 0.00 | 1.16 ± 0.07 | 0.5 ± 0.1 | 0.5 |
5′-l-Valyl-gemcitabine | 0.12 ± 0.00 | 0.96 ± 0.11 | 0.5 ± 0.1 | 0.5 |
5′-l-Phenylalanyl-BDCRB | 2.33 ± 0.04 | 0.91 ± 0.02 | 48.0 ± 0.8 | 52.7 |
5′-d-Phenylalanyl-BDCRB | 1.60 ± 0.21 | 0.90 ± 0.28 | 33.0 ± 4.2 | 36.5 |