TABLE 1
Affinity of AVP for the wild type and mutant V
2
Rs
V
2
R
K
d
nM
Wild type
2.23 ± 0.25
K100D
1.92 ± 0.44
A110W
1.96 ± 0.54
M120V
2.38 ± 0.85
L175Y
2.50 ± 0.47
R202S
2.24 ± 0.21
F307I
2.38 ± 0.54