Molecular weights, octanol/phosphate-buffered saline (pH 7.4) partition coefficients (log D), PSe-in and PSe-out, and Q ratio measured with the in vitro human BBB model for the 11 compounds studied
Derivative | Mol. Wt. | Log D (pH 7.4) | PSe-in | PSe-out | Q ratio | |
|---|---|---|---|---|---|---|
| g · mol-1 | μl · min-1 | |||||
| F-A-85380 | 182.2 | -1.49 | 5.68 | 4.48 | 0.9 | |
| FPy 01 | 317.4 | 1.23 | 10.39 | 6.46 | 0.6 | |
| FPy 02 | 281.3 | 0.63 | 10.04 | 36.85 | 3.7 | |
| FPy 03 | 286.3 | 1.93 | 59.42 | 34.26 | 0.6 | |
| FPy 04 | 266.3 | 1.57 | 12.87 | 51.38 | 4.0 | |
| FPy 05 | 585.6 | 1.36 | 3.34 | 8.12 | 2.4 | |
| FPy 06 | 321.4 | 1.95 | 6.47 | 24.87 | 3.8 | |
| FPy 07 | 337.5 | 1.15 | 19.58 | 5.43 | 0.3 | |
| FPy 08 | 300.3 | 1.74 | 16.22 | 12.66 | 0.8 | |
| FPy 09 | 315.3 | 1.76 | 8.70 | 3.91 | 0.5 | |
| FPy 10 | 295.4 | 1.74 | 1.68 | 3.67 | 2.2 | |