TABLE 2

Antinociceptive effects of i.v. ARD-353 in mouse tail pinch assay

Time after Dosing (min)
0
2
5
10
20
30
60
90
120
Route
Dose
Mean Tail Pinch Response Time
s
i.v. 10 mg/kg 1 ± 0 1 ± 0 1 ± 0 1 ± 0 1 ± 0 1 ± 0
50 mg/kg 1 ± 0 1 ± 0 1 ± 0 1 ± 0 1 ± 0 1 ± 0
p.o. 100 mg/kg 1 ± 0 1 ± 0 1 ± 0 1 ± 0 1 ± 0 1 ± 0
s.c.
100 mg/kg
1 ± 0
1 ± 0
1 ± 0
1 ± 0
1 ± 0
1 ± 0