Efficacy of TPA023 at human recombinant GABAA receptors containing different α subunits stably expressed in mouse fibroblast L(tk-) cells
Human Recombinant GABAA Receptors Containing β3, γ2 plus | |||||||
|---|---|---|---|---|---|---|---|
| α1 | α2 | α3 | α5 | ||||
| Maximum % modulationa | 1 ± 4 (5) | 12 ± 5 (5) | 33 ± 3 (5) | 6 ± 2 (6) | |||
| Efficacy relative to CDP | 0.00 ± 0.03 | 0.11 ± 0.03 | 0.21 ± 0.03 | 0.05 ± 0.02 | |||
CDP, chlordiazepoxide.
↵ a Mean ± S.E.M. of modulation observed in each individual cell (figures in parentheses = n)