TABLE 1

Affinity of TPA023 for human recombinant GABA_A receptors containing different α subunits and native rat brain receptors Data shown are the mean ± S.E.M. (n = 3–5 separate determinations).

K_i
Human Recombinant GABA_A Receptors Containing β3, γ2 plus								Native Rat Brain Receptor
α1	α2	α3	α4	α5	α6	Cerebellum	Spinal Cord
nM								nM
0.27 ± 0.04	0.31 ± 0.03	0.19 ± 0.01	60 ± 7	0.41 ± 0.09	418 ± 72	0.33 ± 0.05	0.32 ± 0.01