Characteristics of experimental groups: body weights and plasma lipid profiles of mice prior to sacrifice Treatment with COOH decreased total cholesterol in the db/+ (***, P < 0.001) and triglycerides in all other animal groups (**, P < 0.05; *, P < 0.01; ##, P < 0.05). Malondialdehyde levels (MDA; a marker of lipid peroxidation) did not show statistically significant differences between groups when normalized to total cholesterol.
Mouse Weight | S.E.M. | Total Cholesterol | S.E.M. | Triglycerides | S.E.M. | MDA/Cholesterol | S.E.M. | No. Animals | |
|---|---|---|---|---|---|---|---|---|---|
| g | mM | mM | |||||||
| db/+ | 30.0 | 1.4 | 1.81*** | 0.06 | 1.18 | 0.11 | 4.94 | 0.58 | 5 |
| db/+-treated | 32.0 | 1.3 | 1.35*** | 0.08 | 0.94 | 0.08 | 5.20 | 0.58 | 5 |
| db/db | 51.5 | 1.6 | 2.77 | 0.11 | 2.11** | 0.61 | 5.41 | 0.31 | 5 |
| db/db-treated | 54.3 | 1.8 | 2.66 | 0.15 | 1.04** | 0.20 | 4.59 | 0.46 | 5 |
| ob/+ | 30.2 | 0.6 | 2.06 | 0.12 | 1.53* | 0.07 | 4.28 | 0.70 | 3 |
| ob/+-treated | 31.7 | 0.4 | 1.73 | 0.14 | 0.90* | 0.01 | 3.51 | 0.62 | 3 |
| ob/ob | 60.7 | 2.6 | 4.30 | 0.12 | 1.60## | 0.21 | 5.30 | 1.10 | 3 |
| ob/ob-treated | 65.4 | 2.8 | 3.90 | 0.22 | 0.77## | 0.05 | 3.96 | 0.63 | 3 |