Inhibiting Drug | IC50 (μM)a | fu | Affected Drug | Largest Predicted Magnitude of Drug Interactionb | Actual Drug Interaction | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Testosterone | Midazolam | Felodipine | [I] = Csys | [I] = fu × Csys | [I] = Chep,inlet(est) | [I] = fu × Chep,inlet(est) | |||||||||
Alprazolam | >300 | >300 | >300 | 0.29 | Buspirone | 1.00 | 1.00 | 1.00 | 1.00 | 1.29 | |||||
Atenolol | >300 | >300 | >300 | 1 | Nifedipine | 1.02 | 1.02 | 1.03 | 1.03 | 0.98 | |||||
Atorvastatin | 300 | 16 | 36 | 0.02 | Midazolam i.v. | 1.00 | 1.00 | 1.07 | 1.00 | 1.41 | |||||
Azithromycin | >300 | >300 | >300 | 0.12 | Midazolam | 1.05 | 1.05 | 1.07 | 1.05 | 1.27 | |||||
Buspirone | 70 | 59 | >300 | 0.05 | Alprazolam | 1.00 | 1.00 | 1.04 | 1.00 | 1.08 | |||||
Caffeine | >300 | >300 | >300 | 0.64 | Alprazolam | 1.02 | 1.01 | 1.03 | 1.02 | 1.08 | |||||
Cimetidinec | 230 | >300 | >300 | 0.79 | Triazolam | 1.29 | 1.27 | 1.75 | 1.64 | 2.20 | |||||
Citalopram | >300 | >300 | >300 | 0.20 | Alprazolam | 1.00 | 1.00 | 1.00 | 1.00 | 1.02 | |||||
Clarithromycinc | >300 | 99 | >300 | 0.30 | Midazolam | 1.42 | 1.36 | 2.00 | 1.54 | 9.61 | |||||
Cyclosporin | 4.5 | 1.4 | 300 | 0.07 | Simvastatin | 2.52 | 1.54 | 4.83 | 1.74 | 2.55 | |||||
Digoxin | >300 | >300 | >300 | 0.75 | Nifedipine | 1.00 | 1.00 | 1.00 | 1.00 | 0.98 | |||||
Diltiazemc | 60 | 83 | >300 | 0.22 | Buspirone | 1.40 | 1.39 | 1.76 | 1.48 | 5.33 | |||||
Disulfiram | 6.9 | 3.6 | 7.9 | 0.04 | Midazolam | 1.74 | 1.74 | 13.8 | 2.70 | 0.94 | |||||
Erythromycinc | 220 | 18 | 16 | 0.16 | Buspirone | 4.64 | 3.42 | 12.2 | 4.95 | 5.91 | |||||
Fluconazole | 17 | 6.8 | 23 | 0.89 | Midazolam | 7.64 | 7.15 | 10.5 | 9.86 | 3.60 | |||||
Fluoxetine | 16 | 36 | 88 | 0.05 | Alprazolam | 1.04 | 1.01 | 1.16 | 1.01 | 1.32 | |||||
Fluvoxamine | 28 | 43 | 62 | 0.23 | Buspirone | 2.41 | 2.38 | 3.40 | 2.61 | 2.40 | |||||
Gatifloxacin | >300 | >300 | >300 | 0.80 | Midazolam i.v. | 1.02 | 1.01 | 1.06 | 1.05 | 1.08 | |||||
Gemfibrozil | >300 | >300 | >300 | 0.03 | Simvastatin | 1.31 | 1.15 | 1.51 | 1.15 | 1.43 | |||||
Itraconazole | 0.010 | 0.045 | 0.021 | 0.002 | Buspirone | 59.5 | 5.56 | 67.3 | 14.3 | 18.2 | |||||
Ketoconazole | 0.012 | 0.011 | 0.019 | 0.01 | Midazolam | 24.5 | 8.50 | 25.0 | 18.2 | 17.0 | |||||
Metoprolol | >300 | >300 | >300 | 0.89 | Nifedipine | 1.02 | 1.02 | 1.05 | 1.05 | 1.05 | |||||
Metronidazole | >300 | >300 | >300 | 0.89 | Midazolam | 1.39 | 1.36 | 1.59 | 1.55 | 0.93 | |||||
Mibefradilc | 0.33 | 0.19 | 0.68 | 0.005 | Midazolam | 10.3 | 1.82 | 20.0 | 2.16 | 8.86 | |||||
Nefazodonec | 1.4 | 0.90 | 8.6 | 0.009 | Midazolam | 10.3 | 1.87 | 19.6 | 2.42 | 5.44 | |||||
Nelfinavirc | 0.65 | 0.17 | 0.18 | 0.015 | Simvastatin | 19.3 | 3.54 | 21.4 | 12.7 | 6.07 | |||||
Omeprazole | 110 | 68.4 | >300 | 0.05 | Nifedipine | 1.05 | 1.04 | 1.08 | 1.04 | 1.25 | |||||
Paroxetine | 23 | 23 | 17 | 0.05 | Alprazolam | 1.02 | 1.01 | 1.12 | 1.01 | 0.99 | |||||
Propoxyphene | 72 | 84 | 140 | 0.24 | Alprazolam | 1.01 | 1.01 | 1.31 | 1.08 | 1.60 | |||||
Propranolol | 140 | >300 | >300 | 0.10 | Alprazolam | 1.01 | 1.00 | 1.26 | 1.03 | 1.38 | |||||
Quinidine | 140 | 58 | >300 | 0.13 | Nifedipine | 1.31 | 1.24 | 2.69 | 1.44 | 1.37 | |||||
Ranitidine | >300 | >300 | >300 | 0.85 | Midazolam | 1.05 | 1.05 | 1.09 | 1.08 | 1.69 | |||||
Repaglinide | 180 | >300 | 120 | 0.026 | Nifedipine | 1.00 | 1.00 | 1.01 | 1.00 | 1.09 | |||||
Ritonavirc | 0.0088 | 0.0042 | 0.0037 | 0.015 | Triazolam | 22.2 | 17.0 | 22.3 | 20.3 | 20.3 | |||||
Roxithromycin | >300 | 68 | >300 | 0.14 | Midazolam | 1.53 | 1.24 | 1.74 | 1.27 | 1.47 | |||||
Saquinavirc | 2.0 | 0.82 | 0.51 | 0.02 | Midazolam | 16.9 | 2.58 | 24.4 | 10.9 | 5.17 | |||||
Sertraline | 8.6 | 16 | 18 | 0.02 | Alprazolam | 1.05 | 1.01 | 1.52 | 1.02 | 1.00 | |||||
Simvastatin | 2.0 | 0.77 | 2.6 | 0.06 | Midazolam | 1.65 | 1.49 | 2.32 | 1.53 | 1.13 | |||||
Terbinafine | >300 | >300 | >300 | 0.01 | Midazolam | 1.07 | 1.06 | 1.10 | 1.06 | 0.75 | |||||
Troleandomycinc | 9.3 | 2.6 | 12 | 0.15 | Midazolam | 3.72 | 2.05 | 14.8 | 5.54 | 4.10 | |||||
Venlafaxine | >300 | >300 | >300 | 0.73 | Alprazolam | 1.00 | 1.00 | 1.02 | 1.01 | 0.98 | |||||
Verapamilc | 23 | 23 | 50 | 0.10 | Midazolam | 1.45 | 1.40 | 2.62 | 1.52 | 2.91 |