Summary of predictions of drug-drug interactions for CYP2C19
Inhibiting Drug | IC50a | fu | Affected Drug | Predicted Magnitude of Drug Interaction | Actual Drug Interaction | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| [I] = Csys | [I] = fu × Csys | [I] = Chep,inlet(est) | [I] = fu × Chep,inlet(est) | ||||||||
| μM | |||||||||||
| Citalopram | >300 | 0.20 | Mephenytoin | 1.00 | 1.00 | 1.01 | 1.00 | 1.00 | |||
| Clarithromycin | >300 | 0.30 | Omeprazole | 1.00 | 1.00 | 1.04 | 1.01 | 2.12 | |||
| Disulfiram | 5.5 | 0.04 | Mephenytoin | 1.00 | 1.00 | 6.08 | 1.20 | 1.00 | |||
| Fluconazole | 5.8 | 0.89 | Omeprazole | 3.93 | 3.73 | 4.47 | 4.28 | 6.29 | |||
| Fluvoxamine | 0.35 | 0.23 | Mephenytoin | 2.67 | 1.38 | 35.2 | 8.87 | 9.89 | |||
| Ketoconazole | 9.4 | 0.01 | Omeprazole | 1.54 | 1.01 | 2.10 | 1.01 | 1.36 | |||
| Moclobemide | 160 | 0.50 | Omeprazole | 1.14 | 1.07 | 1.37 | 1.19 | 1.96 | |||
| Paroxetine | 22 | 0.05 | Mephenytoin | 1.04 | 1.00 | 1.50 | 1.02 | 1.00 | |||
| Risperidone | 290 | 0.11 | Mephenytoin | 1.00 | 1.00 | 1.00 | 1.00 | 1.09 | |||
| Roxithromycin | >300 | 0.14 | Omeprazole | 1.04 | 1.01 | 1.08 | 1.01 | 1.31 | |||
| Ticlopidineb | 0.78 | 0.02 | Omeprazole | 4.37 | 1.13 | 7.01 | 2.01 | 2.39 | |||
| Troleandomycin | >300 | 0.15c | Omeprazole | 1.01 | 1.00 | 1.05 | 1.01 | 1.26 | |||